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In 1977, Sanger developed a much simpler sequencing method, called “chain termination,” which is today known simply as Sanger sequencing. This technique took advantage of a different type of special nucleotide called a dideoxyribonucleotide, or ddNTP. ddNTPs lack one of the hydroxyl groups present on a normal dNTP, preventing the chemical reaction necessary to add another nucleotide and terminating DNA elongation.

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The decision came six weeks after the FBI executed the search warrant at the Virginia home of reporter Hannah Natanson. Porter declined the Post and Natanson's request to return the devices immediately but decided on a court-led process to ensure that the search is limited to materials that may aid a criminal case against an alleged leaker who was in contact with Natanson. He also rescinded the portion of the search warrant that authorized the government to open, access, review, or otherwise examine the seized data.

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